Lactate Dehydrogenase A Antikörper (N-Term)

Produktnummer ABIN2774085

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Lactate Dehydrogenase A in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Kaninchen, Rind (Kuh), Pferd, Hund, Meerschweinchen, Ziege und Schaf. Es wurde in 3+ Publikationen zitiert.

Kurzübersicht für Lactate Dehydrogenase A Antikörper (N-Term) (ABIN2774085)

Target: Lactate Dehydrogenase A (LDHA)

Reaktivität: Human, Maus, Ratte, Kaninchen, Rind (Kuh), Pferd, Hund, Meerschweinchen, Ziege, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Lactate Dehydrogenase A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Lactate Dehydrogenase A Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: LDHA Antibody - N-terminal region

Sequenz: ATLKDQLIYN LLKEEQTPQN KITVVGVGAV GMACAISILM KDLADELALV

Homologie: Cow: 86%, Dog: 86%, Goat: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rabbit: 92%, Rat: 93%, Sheep: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against LDHA. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LDHA

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP54776-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Lactate Dehydrogenase A Antikörper (ABIN2774085)

Schönrogge, Kerndl, Zhang, Kumstel, Vollmar, Zechner: "α-cyano-4-hydroxycinnamate impairs pancreatic cancer cells by stimulating the p38 signaling pathway." in: Cellular signalling, Vol. 47, pp. 101-108, (2018) (PubMed).

Zechner, Bürtin, Albert, Zhang, Kumstel, Schönrogge, Graffunder, Shih, Müller, Radecke, Jaster, Vollmar: "Intratumoral heterogeneity of the therapeutical response to gemcitabine and metformin." in: Oncotarget, Vol. 7, Issue 35, pp. 56395-56407, (2018) (PubMed).

Listerman, Bledau, Grishina, Neugebauer: "Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III." in: PLoS genetics, Vol. 3, Issue 11, pp. e212, (2008) (PubMed).

Details zu Lactate Dehydrogenase A

Target: Lactate Dehydrogenase A (LDHA)

Andere Bezeichnung: LDHA

Hintergrund:

Background Information: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene.

Gene Name: lactate dehydrogenase A

Alternative Symbols: LDHM, GSD11, PIG19, HEL-S-133P

Protein Name: L-lactate dehydrogenase A chain

Molekulargewicht: 37 kDa

Gen-ID: 3939

NCBI Accession: NP_005557

UniProt: P00338

Pathways: Warburg Effekt