PNKP Antikörper (N-Term)

Produktnummer ABIN2774011

Produktdetails anti-PNKP Antikörper

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PNKP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PNKP. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human PNKP

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 521 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu PNKP

Target: PNKP (Polynucleotide Kinase 3'-Phosphatase (PNKP))

Andere Bezeichnung: PNKP (PNKP Produkte)

Hintergrund: This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
Alias Symbols: PNK, MCSZ, EIEE10
Protein Interaction Partner: ZNF639, IKZF1, TNIP1, ZBTB14, RPA3, RPA2, RPA1, EED, rev, KDM1A, SUV39H1, HNRNPU, GZMK, XRCC6, CDK11B, PARP1, MCM3, SMAD5, LIG4, XRCC1, TCOF1, SSRP1, PRKDC, NRD1, NASP, MCM5, C18orf25, UBE2O, GEMIN4, AGTPBP1, PNKP, SUPT16H, VPRBP, NOLC1, TRIM26, XRCC5, XR
Protein Size: 521

Molekulargewicht: 57 kDa

Gen-ID: 11284

NCBI Accession: NM_007254, NP_009185

UniProt: Q96T60

Pathways: DNA Reparatur, Nucleotide Phosphorylation