HLA-F Antikörper (N-Term)

Produktnummer ABIN2773941

Der Kaninchen Polyklonal anti-HLA-F Antikörper (ABIN2773941) detektiert spezifisch HLA-F in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Schwein und Rind (Kuh).

Kurzübersicht für HLA-F Antikörper (N-Term) (ABIN2773941)

Target: HLA-F (HLAF) (HLA Class I alpha F (HLAF))

Reaktivität: Human, Schwein, Rind (Kuh)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-F Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-HLA-F Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: HLA-F Antibody - N-terminal region

Sequenz: EAGSHTLQGM NGCDMGPDGR LLRGYHQHAY DGKDYISLNE DLRSWTAADT

Homologie: Cow: 93%, Human: 100%, Pig: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against HLA-F. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human HLA-F

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP49411-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu HLA-F

Target: HLA-F (HLAF) (HLA Class I alpha F (HLAF))

Andere Bezeichnung: HLA-F

Hintergrund:

Background Information: HLA-F belongs to the HLA class I heavy chain paralogues. It is a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.

Gene Name: Major histocompatibility complex, class I, F

Alternative Symbols: HLAF, CDA12, HLA-5.4, HLA-CDA12

Protein Name: HLA class I histocompatibility antigen, alpha chain F

Molekulargewicht: 48kDa

Gen-ID: 3134

NCBI Accession: NP_001091949

UniProt: P30511

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response