PRP19 Antikörper (Middle Region)

Produktnummer ABIN2773819

Produktdetails anti-PRP19 Antikörper

Target: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen, Zebrafisch (Danio rerio), Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRP19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: PSVVGAGEPM DLGELVGMTP EIIQKLQDKA TVLTTERKKR GKTVPEELVK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against PRPF19. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PRPF19

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 504 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PRP19 Antikörper (ABIN2773819)

Song, Cui, Zhong, Han: "Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium." in: Journal of clinical pathology, Vol. 62, Issue 9, pp. 802-7, (2009) (PubMed).

Details zu PRP19

Target: PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))

Andere Bezeichnung: PRPF19 (PRPF19 Produkte)

Synonyme: NMP200 antikoerper, fb18f09 antikoerper, zgc:56158 antikoerper, wu:fb18f09 antikoerper, nmp200 antikoerper, PRP19 antikoerper, PSO4 antikoerper, SNEV antikoerper, UBOX4 antikoerper, hPSO4 antikoerper, Prp19 antikoerper, nmp-200 antikoerper, AA617263 antikoerper, AL024362 antikoerper, D19Wsu55e antikoerper, Snev antikoerper, pre-mRNA processing factor 19 antikoerper, pre-mRNA processing factor 19 L homeolog antikoerper, prpf19 antikoerper, prpf19.L antikoerper, PRPF19 antikoerper, Prpf19 antikoerper

Hintergrund: PRPF19 plays a role in DNA double-strand break (DSB) repair and pre-mRNA splicing reaction. It binds double-stranded DNA in a sequence-nonspecific manner. PRPF19 acts as a structural component of the nuclear framework. It may also serve as a support for spliceosome binding and activity. It is essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. It also may have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Overexpression of PRPF19 might extend the cellular life span by increasing the resistance to stress or by improving the DNA repair capacity of the cells.In S. cerevisiae, Pso4 has pleiotropic functions in DNA recombination and in error-prone nonhomologous end-joining DNA repair.[supplied by OMIM].
Alias Symbols: NMP200, PRP19, PSO4, UBOX4, hPSO4, SNEV
Protein Interaction Partner: HUWE1, USP4, UBE2D3, SUMO2, CEP76, CEP250, TUBGCP3, CEP57, VCP, UBC, SUMO1, NEDD8, LIN28A, EXOC7, EXOC3, RPA3, RPA2, RPA1, RNF2, SUZ12, EED, rev, MEPCE, SEC13, PARK2, TARDBP, UBD, CSNK2A2, UCHL5, WHSC1, U2AF1, PRCC, HSP90AA1, HSPB1, FN1, RBM10, vif, CDC40
Protein Size: 504

Molekulargewicht: 55 kDa

Gen-ID: 27339

NCBI Accession: NM_014502, NP_055317

UniProt: Q9UMS4

Pathways: Ribonucleoprotein Complex Subunit Organization