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PRP19 Antikörper (N-Term)

PRPF19 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259137
  • Target Alle PRP19 (PRPF19) Antikörper anzeigen
    PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))
    Bindungsspezifität
    • 9
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 65
    • 50
    • 32
    • 8
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 61
    • 3
    • 1
    Kaninchen
    Klonalität
    • 53
    • 12
    Polyklonal
    Konjugat
    • 32
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    Dieser PRP19 Antikörper ist unkonjugiert
    Applikation
    • 46
    • 29
    • 26
    • 15
    • 9
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    PRPF19 Antibody detects endogenous levels of total PRPF19.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PRPF19, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product PRPF19 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))
    Andere Bezeichnung
    PRPF19 (PRPF19 Produkte)
    Synonyme
    NMP200 antikoerper, fb18f09 antikoerper, zgc:56158 antikoerper, wu:fb18f09 antikoerper, nmp200 antikoerper, PRP19 antikoerper, PSO4 antikoerper, SNEV antikoerper, UBOX4 antikoerper, hPSO4 antikoerper, Prp19 antikoerper, nmp-200 antikoerper, AA617263 antikoerper, AL024362 antikoerper, D19Wsu55e antikoerper, Snev antikoerper, pre-mRNA processing factor 19 antikoerper, pre-mRNA processing factor 19 L homeolog antikoerper, prpf19 antikoerper, prpf19.L antikoerper, PRPF19 antikoerper, Prpf19 antikoerper
    Hintergrund

    Description: Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity).

    Gene: PRPF19

    Molekulargewicht
    50 kDa
    Gen-ID
    27339
    UniProt
    Q9UMS4
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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