BHMT Antikörper (N-Term)

Produktnummer ABIN2773785

Der Kaninchen Polyklonal Anti-BHMT-Antikörper wurde für WB und IHC validiert. Er ist geeignet, BHMT in Proben von Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Rind (Kuh), Kaninchen und Zebrafisch (Danio rerio) zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für BHMT Antikörper (N-Term) (ABIN2773785)

Target: BHMT (Betaine--Homocysteine S-Methyltransferase (BHMT))

Reaktivität: Human, Maus, Ratte, Hund, Meerschweinchen, Pferd, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BHMT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-BHMT Antikörper

Bindungsspezifität: N-Term

Sequenz: AVEHPEAVRQ LHREFLRAGS NVMQTFTFYA SEDKLENRGN YVLEKISGQE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against BHMT. It was validated on Western Blot and immunohistochemistry.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human BHMT

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 406 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-BHMT Antikörper (ABIN2773785)

Jiang, Hurt, Breen, Stabler, Allen, Orlicky, Maclean: "Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap." in: Biology open, Vol. 4, Issue 9, pp. 1154-62, (2015) (PubMed).

Hu, Lausted, Yoo, Yan, Brightman, Chen, Wang, Bu, Hood: "Quantitative liver-specific protein fingerprint in blood: a signature for hepatotoxicity." in: Theranostics, Vol. 4, Issue 2, pp. 215-28, (2014) (PubMed).

Maclean, Jiang, Greiner, Allen, Stabler et al.: "Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine ..." in: Molecular genetics and metabolism, Vol. 105, Issue 3, pp. 395-403, (2012) (PubMed).

Details zu BHMT

Target: BHMT (Betaine--Homocysteine S-Methyltransferase (BHMT))

Andere Bezeichnung: BHMT

Hintergrund: BHMT is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in its gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed.Betaine-homocysteine methyltransferase is a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in BHMT could lead to hyperhomocyst(e)inemia,but such a defect has not yet been observed.
Alias Symbols: BHMT1
Protein Interaction Partner: BHMT, BBS4, BBS2, BBS1, ALG9, LAMTOR3,
Protein Size: 406

Molekulargewicht: 45 kDa

Gen-ID: 635

NCBI Accession: NM_001713, NP_001704

UniProt: Q93088

Pathways: Methionine Biosynthetic Process