SPARC Antikörper (Biotin)

Produktnummer ABIN2764164

Der Biotin-konjugierte Kaninchen Polyklonal anti-SPARC Antikörper (ABIN2764164) detektiert spezifisch SPARC in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für SPARC Antikörper (Biotin) (ABIN2764164)

Target: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPARC Antikörper ist konjugiert mit Biotin

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-SPARC Antikörper (Biotin)

Kreuzreaktivität: Human

Produktmerkmale: Secreted Protein Acidic and Rich in Cysteine, SPARC, SPARC-related modular calcium-binding protein 2 [Precursor], Secreted modular calcium-binding protein 2, SMOC-2, Smooth muscle-associated protein 2, SMAP-2,SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 -UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer. SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).

Aufreinigung: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from the human SPARC protein.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Antibody can be used immunohistochemistry (0.5-1 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu SPARC

Target: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Andere Bezeichnung: SPARC

UniProt: P09486

Pathways: Autophagie