HCRTR1 Antikörper (N-Term)

Produktnummer ABIN2764055

Der Kaninchen Polyklonal Anti-HCRTR1-Antikörper wurde für ELISA validiert. Er ist geeignet, HCRTR1 in Proben von Human zu detektieren.

Kurzübersicht für HCRTR1 Antikörper (N-Term) (ABIN2764055)

Target: HCRTR1 (Hypocretin (Orexin) Receptor 1 (HCRTR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HCRTR1 Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-HCRTR1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human

Produktmerkmale: Ox1r, Hypocretin receptor type 1,As first published in 1998 by Sakurai et al, the initial neuropeptides Orexin A and Orexin B were shown to be important in the regulation of appetite. Continued research now suggests that these peptides also influence a wide range of physiological and behavioral processes such as increased EFG arousal and wakefulness and locomotor activity. In addition to the orexins , two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides1. Recently Orexin Receptors have been found to activate extracellular signal-regulated kinases in CHO cells, namely ERK phosporylation, through Ca2+ influx..2. Further studies seem to indicate a mechanism for orexin receptor mediated cell death and suggest a pathway from GPCRs to apoptosis throughthe MAPK pathways.3

Aufreinigung: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide made to the N terminal of human Orexin Receptor 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for Western blotting at Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Immunoaffinity antibody povided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu HCRTR1

Target: HCRTR1 (Hypocretin (Orexin) Receptor 1 (HCRTR1))

Andere Bezeichnung: Orexin Receptor-1

UniProt: O43613

Pathways: Feeding Behaviour