H2AFX Antikörper (pSer140)

Produktnummer ABIN2763904

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch H2AFX in WB, IHC und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für H2AFX Antikörper (pSer140) (ABIN2763904)

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H2AFX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Enzyme Immunoassay (EIA)

Produktdetails anti-H2AFX Antikörper

Bindungsspezifität: pSer140

Kreuzreaktivität: Human

Produktmerkmale: H2AFX, H2AX,Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Aufreinigung: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from human histone H2a.x protein. Sequence is unphosphorylated version of peptide.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for immunohistochemical staining (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu H2AFX

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Andere Bezeichnung: Histone H2A.x

UniProt: P16104

Pathways: Telomere Maintenance, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus