H2AFX Antikörper (pSer140)

Produktnummer ABIN2763904

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch H2AFX in WB, IHC und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für H2AFX Antikörper (pSer140) (ABIN2763904)

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser H2AFX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Enzyme Immunoassay (EIA)

Produktdetails anti-H2AFX Antikörper

Bindungsspezifität: pSer140

Kreuzreaktivität: Human

Produktmerkmale: H2AFX, H2AX,Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Aufreinigung: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from human histone H2a.x protein. Sequence is unphosphorylated version of peptide.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for immunohistochemical staining (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu H2AFX

Target: H2AFX (H2A Histone Family, Member X (H2AFX))

Andere Bezeichnung: Histone H2A.x

UniProt: P16104

Pathways: Telomere Maintenance, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus