H2AFX Antikörper (pSer140)
Kurzübersicht für H2AFX Antikörper (pSer140) (ABIN2763904)
Target
Alle H2AFX Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- pSer140
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Kreuzreaktivität
- Human
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Produktmerkmale
- H2AFX, H2AX,Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
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Aufreinigung
- Antigen Immunoaffiinity Purification
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Immunogen
- Synthetic peptide derived from human histone H2a.x protein. Sequence is unphosphorylated version of peptide.
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Isotyp
- IgG
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anti-H2A Histone Family, Member X (H2AFX) (AA 115-143), (C-Term) antibody
H2AFX Reaktivität: Human WB, IHC (p) Wirt: Maus Monoclonal 938CT5-1-1 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibodyH2AFX Reaktivität: Human, Maus WB, BI Wirt: Maus Monoclonal N1-431 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (H2AXS139ph) antibodyH2AFX Reaktivität: Human WB, ELISA, IF, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (ubLys119) antibodyH2AFX Reaktivität: Human, Maus, Ratte WB, ELISA, ICC, IHC (p), IF (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer140) antibodyH2AFX Reaktivität: Human WB, ELISA, ICC, IHC (p), FACS, IF (p), IF (cc), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) antibodyH2AFX Reaktivität: Human WB, ICC, FACS Wirt: Kaninchen Monoclonal 23GB6040 unconjugated Recombinant Antibody
anti-H2A Histone Family, Member X (H2AFX) (H2A.XS139ph) antibodyH2AFX Reaktivität: Human WB, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-H2A Histone Family, Member X (H2AFX) antibodyH2AFX Reaktivität: Human WB, IHC (p) Wirt: Maus Monoclonal 8C5 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (AA 1-30), (N-Term) antibodyH2AFX Reaktivität: Human WB, IHC (p) Wirt: Maus Monoclonal 980CT1-5-5 unconjugated
anti-H2A Histone Family, Member X (H2AFX) (pSer139) antibodyH2AFX Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Antibody can be used for immunohistochemical staining (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- Provided as solution in phosphate buffered saline with 0.08 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- H2AFX (H2A Histone Family, Member X (H2AFX))
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Andere Bezeichnung
- Histone H2A.x
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UniProt
- P16104
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Pathways
- Telomere Maintenance, DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus
Target
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