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Sialoadhesin/CD169 Antikörper (PE)

SIGLEC1 Reaktivität: Human FACS Wirt: Maus Monoclonal 7-239 PE
Produktnummer ABIN2749112
  • Target Alle Sialoadhesin/CD169 (SIGLEC1) Antikörper anzeigen
    Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))
    Reaktivität
    • 47
    • 23
    • 20
    • 4
    • 3
    Human
    Wirt
    • 36
    • 18
    • 18
    • 4
    Maus
    Klonalität
    • 38
    • 35
    • 1
    Monoklonal
    Konjugat
    • 32
    • 9
    • 9
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Sialoadhesin/CD169 Antikörper ist konjugiert mit PE
    Applikation
    • 45
    • 30
    • 23
    • 20
    • 15
    • 13
    • 13
    • 13
    • 10
    • 7
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The mouse monoclonal antibody 7-239 recognizes an extracellular epitope of CD169 (sialoadhesin, Siglec-1), a 210 kDa type I transmembrane glycoprotein expressed on macrophages and dendritic cells.
    Kreuzreaktivität (Details)
    Human
    Aufreinigung
    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    human rhinovirus 14-infected monocyte-derived dendritic cells
    Klon
    7-239
    Isotyp
    IgG1
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    Discover our top product SIGLEC1 Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Kawasaki, Vela, Nycholat, Rademacher, Khurana, van Rooijen, Crocker, Kronenberg, Paulson: "Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 19, pp. 7826-31, (2013) (PubMed).

    Schrauf, Kirchberger, Majdic, Seyerl, Zlabinger, Stuhlmeier, Sachet, Seipelt, Stöckl: "The ssRNA genome of human rhinovirus induces a type I IFN response but fails to induce maturation in human monocyte-derived dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 7, pp. 4440-8, (2009) (PubMed).

  • Target
    Sialoadhesin/CD169 (SIGLEC1) (Sialic Acid Binding Ig-Like Lectin 1, Sialoadhesin (SIGLEC1))
    Andere Bezeichnung
    CD169 / Siglec-1 (SIGLEC1 Produkte)
    Synonyme
    Cd169 antikoerper, Siglec-1 antikoerper, Sn antikoerper, CD169 antikoerper, SIGLEC-1 antikoerper, SN antikoerper, dJ1009E24.1 antikoerper, SA antikoerper, SIGLEC1 antikoerper, p210 antikoerper, pSn antikoerper, sialic acid binding Ig like lectin 1 antikoerper, sialic acid binding Ig-like lectin 1, sialoadhesin antikoerper, SIGLEC1 antikoerper, Siglec1 antikoerper
    Hintergrund
    Sialic acid binding Ig like lectin 1,CD169, also known as Siglec-1 or sialoadhesin, is a type I transmembrane glycoprotein of the sialic acid binding Ig-like lectin family. It binds to sialylated glycoproteins on various haematopoietic cells to mediate cell-cell interactions. CD169 is expressed on a subset of macrophages and dendritic cells. On CD14+ monocytes its expression can be induced by interferon alpha and gamma. High expression of CD169 is observed in the spleen, lymph nodes, bone marrow, and under inflammatory conditions rheumatoid arthritis and atherosclerosis, lower in the liver, lungs and gut. It has been shown to be involved in antigen presentation to invariant NKT cells, which play an important role in the innate arm of the immune system to modulate the subsequent acquired immune responses.,SIGLEC1, SN, sialoadhesin
    Gen-ID
    6614
    UniProt
    Q9BZZ2
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