PDE5A Antikörper (C-Term)

Produktnummer ABIN2747175

Es sind 16+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-PDE5A Antikörper wird verwendet zum Nachweis von PDE5A in Proben von Human und Huhn. Er wurde validiert für WB, ELISA, IHC, IP, ICC, IF und CM.

Kurzübersicht für PDE5A Antikörper (C-Term) (ABIN2747175)

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Reaktivität: Human, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE5A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Confocal Microscopy (CM)

Produktdetails anti-PDE5A Antikörper

Bindungsspezifität: AA 825-875, C-Term

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide common to all PDE5A variants taken within amino acid region 825-875 on human PDE5A protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.55-0.60 μg/μL

Referenzen für anti-PDE5A Antikörper (ABIN2747175)

Carøe Nordgaard, Kruse, Gammeltoft, Kruuse: "Role of Ser102 and Ser104 as regulators of cGMP hydrolysis by PDE5A." in: PLoS ONE, Vol. 9, Issue 9, pp. e107627, (2015) (PubMed).

Rajagopal, Nalli, Kumar, Bhattacharya, Hu, Mahavadi, Grider, Murthy: "Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation." in: The Journal of pharmacology and experimental therapeutics, Vol. 352, Issue 3, pp. 509-18, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Witting, Kruuse, Nyhuus, Prahm, Citirak, Lundgaard, von Huth, Vejlstrup, Lindberg, Krag, Vissing: "Effect of sildenafil on skeletal and cardiac muscle in Becker muscular dystrophy." in: Annals of neurology, Vol. 76, Issue 4, pp. 550-7, (2014) (PubMed).

Ückert, Oelke, Albrecht, Breitmeier, Kuczyk, Hedlund: "Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)." in: International journal of impotence research, Vol. 23, Issue 5, pp. 206-12, (2012) (PubMed).

Ückert, Waldkirch, Sonnenberg, Sandner, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).

Mietens, Tasch, Feuerstacke, Eichner, Volkmann, Schermuly, Grimminger, Müller, Middendorff: "Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not." in: Molecular and cellular endocrinology, Vol. 349, Issue 2, pp. 145-53, (2012) (PubMed).

Luong, Rey-Perra, Vadivel, Gilmour, Sauve, Koonen, Walker, Todd, Gressens, Kassiri, Nadeem, Morgan, Eaton, Dyck, Archer, Thébaud: "Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia." in: Circulation, Vol. 123, Issue 19, pp. 2120-31, (2011) (PubMed).

Sasseville, Côté, Gagnon, Richard: "Up-regulation of 3'5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation." in: Endocrinology, Vol. 149, Issue 11, pp. 5568-76, (2009) (PubMed).

Albrecht, Uckert, Oelke, Andersson, Jonas, Tröger, Hedlund: "Immunohistochemical distribution of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human vagina: a potential forensic value?" in: Journal of forensic and legal medicine, Vol. 14, Issue 5, pp. 270-4, (2007) (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." in: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, (2007) (PubMed).

Liu, Xin, Xin, Yuan, Tian, Guo: "Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats." in: Asian journal of andrology, Vol. 7, Issue 4, pp. 381-8, (2006) (PubMed).

Werkström, Svensson, Andersson, Hedlund: "Phosphodiesterase 5 in the female pig and human urethra: morphological and functional aspects." in: BJU international, Vol. 98, Issue 2, pp. 414-23, (2006) (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." in: Urology, Vol. 65, Issue 3, pp. 604-10, (2005) (PubMed).

Wang, Gang Zhang, Lan Zhang, Chopp: "Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 25, Issue 9, pp. 1150-8, (2005) (PubMed).

Monfort, Muñoz, Felipo: "Chronic hyperammonemia in vivo impairs long-term potentiation in hippocampus by altering activation of cyclic GMP-dependent-protein kinase and of phosphodiesterase 5." in: Journal of neurochemistry, Vol. 94, Issue 4, pp. 934-42, (2005) (PubMed).

Details zu PDE5A

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Andere Bezeichnung: PDE5A

UniProt: O76074

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling