PDE5A Antikörper (C-Term)

Produktnummer ABIN2789423

Zitiert in 1 Publikation. Der Kaninchen Polyklonal anti-PDE5A Antikörper (ABIN2789423) detektiert spezifisch PDE5A in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen und Zebrafisch (Danio rerio).

Kurzübersicht für PDE5A Antikörper (C-Term) (ABIN2789423)

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Reaktivität: Human, Ratte, Maus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE5A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-PDE5A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: PDE5A Antibody - C-terminal region

Sequenz: TACDLSAITK PWPIQQRIAE LVATEFFDQG DRERKELNIE PTDLMNREKK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 82%

Produktmerkmale: This is a rabbit polyclonal antibody against PDE5A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP63250-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-PDE5A Antikörper (ABIN2789423)

Ioki, Wu, Takayama, Motohashi, Wakai, Funahashi: "A phosphodiesterase type-5 inhibitor, sildenafil, induces sperm capacitation and penetration into porcine oocytes in a chemically defined medium." in: Theriogenology, Vol. 85, Issue 3, pp. 428-33, (2016) (PubMed).

Details zu PDE5A

Target: PDE5A (phosphodiesterase 5A, cGMP-Specific (PDE5A))

Andere Bezeichnung: PDE5A

Hintergrund:

Background Information: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

Gene Name: Phosphodiesterase 5A, cGMP-specific

Alternative Symbols: CN5A, PDE5, CGB-PDE

Protein Name: cGMP-specific 3',5'-cyclic phosphodiesterase

Molekulargewicht: 93kDa

Gen-ID: 8654

NCBI Accession: NP_246273

UniProt: O76074

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling