MERTK Antikörper (phosphorylated)

Produktnummer ABIN2746864

Dieser Anti-MERTK Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von MERTK in WB, IHC, ELISA, IF, FACS, ICC und CM. Geeignet für Human, Maus, Ratte und Affe. Dieses Primary Antibody wurde in 16+ Publikationen zitiert.

Kurzübersicht für MERTK Antikörper (phosphorylated) (ABIN2746864)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MERTK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Produktdetails anti-MERTK Antikörper

Bindungsspezifität: phosphorylated

Aufreinigung: Affinity Purified

Immunogen: Phosphorylated synthetic peptide corresponding to unique amino acid sequence on MerTK protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.63 μg/μL

Referenzen für anti-MERTK Antikörper (ABIN2746864)

Das, Ghatak, Sinha, Chaffee, Ahmed, Parinandi, Wohleb, Sheridan, Sen, Roy: "Correction of MFG-E8 Resolves Inflammation and Promotes Cutaneous Wound Healing in Diabetes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 12, pp. 5089-100, (2017) (PubMed).

Zhang, Fang, Wu, Ding, Xu, Liu: "Mer receptor tyrosine kinase negatively regulates lipoteichoic acid-induced inflammatory response via PI3K/Akt and SOCS3." in: Molecular immunology, Vol. 76, pp. 98-107, (2017) (PubMed).

Cai, Thorp, Doran, Subramanian, Sansbury, Lin, Spite, Fredman, Tabas: "MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 23, pp. 6526-31, (2016) (PubMed).

Nguyen, Tsou, Calarese, Kimani, Singh, Hsieh, Liu, Lu, Wu, Garforth, Almo, Kotenko, Birge: "Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity." in: The Journal of biological chemistry, Vol. 289, Issue 37, pp. 25737-49, (2015) (PubMed).

Ginisty, Gély-Pernot, Abaamrane, Morel, Arnault, Coronas, Benzakour: "Evidence for a subventricular zone neural stem cell phagocytic activity stimulated by the vitamin K-dependent factor protein S." in: Stem cells (Dayton, Ohio), Vol. 33, Issue 2, pp. 515-25, (2015) (PubMed).

Law, Parinot, Chatagnon, Gravez, Sahel, Bhattacharya, Nandrot: "Cleavage of Mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis." in: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4941-52, (2015) (PubMed).

Wang, Moncayo, Morin, Xue, Grzmil, Lino, Clément-Schatlo, Frank, Merlo, Hemmings: "Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme." in: Oncogene, Vol. 32, Issue 7, pp. 872-82, (2013) (PubMed).

Fraineau, Monvoisin, Clarhaut, Talbot, Simonneau, Kanthou, Kanse, Philippe, Benzakour: "The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner." in: Blood, Vol. 120, Issue 25, pp. 5073-83, (2013) (PubMed).

Choi, Park, Lee, Byun, Youn, Choi, Woo, Kang: "Upregulation of Mer receptor tyrosine kinase signaling attenuated lipopolysaccharide-induced lung inflammation." in: The Journal of pharmacology and experimental therapeutics, Vol. 344, Issue 2, pp. 447-58, (2013) (PubMed).

Qin, Rodrigues: "Roles of αvβ5, FAK and MerTK in oxidative stress inhibition of RPE cell phagocytosis." in: Experimental eye research, Vol. 94, Issue 1, pp. 63-70, (2012) (PubMed).

Lee, Han, Byun, Park, Park, Chong, Cho, Kang: "Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury." in: Journal of leukocyte biology, Vol. 91, Issue 6, pp. 921-32, (2012) (PubMed).

Lee, Lee, Youn, Choi, Song, Cho, Kang: "Preventing cleavage of Mer promotes efferocytosis and suppresses acute lung injury in bleomycin treated mice." in: Toxicology and applied pharmacology, Vol. 263, Issue 1, pp. 61-72, (2012) (PubMed).

Uehara, Shacter: "Auto-oxidation and oligomerization of protein S on the apoptotic cell surface is required for Mer tyrosine kinase-mediated phagocytosis of apoptotic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 4, pp. 2522-30, (2008) (PubMed).

Prasad, Rothlin, Burrola, Burstyn-Cohen, Lu, Garcia de Frutos, Lemke: "TAM receptor function in the retinal pigment epithelium." in: Molecular and cellular neurosciences, Vol. 33, Issue 1, pp. 96-108, (2007) (PubMed).

Sather, Kenyon, Lefkowitz, Liang, Varnum, Henson, Graham: "A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation." in: Blood, Vol. 109, Issue 3, pp. 1026-33, (2007) (PubMed).

Keating, Salzberg, Sather, Liang, Nickoloff, Anwar, Deryckere, Hill, Joung, Sawczyn, Park, Curran-Everett, McGavran, Meltesen, Gore, Johnson, Graham: "Lymphoblastic leukemia/lymphoma in mice overexpressing the Mer (MerTK) receptor tyrosine kinase." in: Oncogene, Vol. 25, Issue 45, pp. 6092-100, (2006) (PubMed).

Details zu MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Andere Bezeichnung: MERTK

UniProt: P57097

Pathways: RTK Signalweg