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PAG1 Antikörper (N-Term)

PAG1 Reaktivität: Human, Maus, Ratte WB, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2745550
  • Target Alle PAG1 Antikörper anzeigen
    PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
    Bindungsspezifität
    • 16
    • 10
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 412-424, N-Term
    Reaktivität
    • 27
    • 26
    • 23
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 42
    • 4
    Kaninchen
    Klonalität
    • 42
    • 4
    Polyklonal
    Konjugat
    • 18
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PAG1 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 16
    • 13
    • 13
    • 12
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Spezifität
    Recognizes mouse, rat and human PAG/Cbp.
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    Antigen affinity purified.
    Immunogen
    Synthetic peptide corresponding to aa 412-424 of the N-terminal rat PAG including an additional N-terminal Cys residue.
    Top Product
    Discover our top product PAG1 Primärantikörper
  • Applikationshinweise
    Positive Control for Western Blot: Use 1.5x106 total splenocytes per lane.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    In PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Haltbarkeit
    12 months
  • Target
    PAG1 (phosphoprotein Associated with Glycosphingolipid Microdomains 1 (PAG1))
    Andere Bezeichnung
    PAG/Cbp (PAG1 Produkte)
    Synonyme
    Cbp antikoerper, F730007C19Rik antikoerper, Pag antikoerper, CBP antikoerper, PAG antikoerper, MGC80192 antikoerper, phosphoprotein associated with glycosphingolipid microdomains 1 antikoerper, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 antikoerper, phosphoprotein membrane anchor with glycosphingolipid microdomains 1 L homeolog antikoerper, Pag1 antikoerper, PAG1 antikoerper, pag1.L antikoerper, pag1 antikoerper
    Hintergrund
    PAG is a ubiquitously expressed transmembrane adapter protein. Depending on its phosphorylation status, it appears as diffuse band(s) of 80-90 kDa by SDS-PAGE, with phosphorylation leading to a shift towards a higher apparent molecular mass. Tyrosine phosphorylated PAG recruits Csk to the membrane and negatively regulates Src family kinases via Csk-mediated phosphorylation. Upon T cell receptor engagement, PAG becomes dephosphorylated, thereby displacing Csk from the membrane and enabling the activation of the Src kinases Fyn and Lck. PAG negatively regulates TCR (T cell antigen receptor)-mediated signaling in T cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. It inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins and may be involved in cell adhesion signaling.
    UniProt
    Q9JM80
    Pathways
    p53 Signalweg, T-Zell Rezeptor Signalweg, EGFR Signaling Pathway, CXCR4-mediated Signaling Events
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