GPX8 Antikörper (AA 38-209)

Produktnummer ABIN2745532

Der Kaninchen Polyklonal anti-GPX8 Antikörper (ABIN2745532) detektiert spezifisch GPX8 in WB und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Hepatitis C Virus (HCV).

Kurzübersicht für GPX8 Antikörper (AA 38-209) (ABIN2745532)

Target: GPX8 (Glutathione Peroxidase 8 (GPX8))

Reaktivität: Hepatitis C Virus (HCV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPX8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC)

Produktdetails anti-GPX8 Antikörper

Bindungsspezifität: AA 38-209

Spezifität: Recognizes human GPx8.

Kreuzreaktivität: Hepatitis C Virus (HCV)

Immunogen: Recombinant GPx8 (human) (aa 38-209) fused to a GST-tag.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Details zu GPX8

Target: GPX8 (Glutathione Peroxidase 8 (GPX8))

Andere Bezeichnung: GPx8

Hintergrund: GPxs are glutathione peroxidases involved in balancing the H2O2 homeostasis in signaling cascades. GPxs have been known to catalyze the reduction of H2O2 or organic hydroperoxides to water or the corresponding alcohols, respectively, typically using glutathione (GSH) as reductant. GPx8 (probable glutathione peroxidase 8) is a 209-aa, 24 kDa protein with an N-terminal cytosolic tip, a predicted transmembrane segment and a catalytic domain located in the endoplasmic reticulum (ER) lumen. GPx8 is a CysGPxs with low glutathione peroxidase activity. A recent study identified GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease. GPx8 cleavage by NS3-4A occurs at Cys11, removing the cytosolic tip of GPx8 and was observed in different experimental systems as well as in liver biopsies from patients with chronic hepatitis C.

UniProt: Q8TED1

Pathways: Thyroid Hormone Synthesis