Keratin 6 Antikörper (C-Term)

Produktnummer ABIN2742495

Produktdetails anti-Keratin 6 Antikörper

Target: Keratin 6 (KRT6)

Bindungsspezifität: C-Term

Reaktivität: Human, Pferd, Orang-Utan, Schimpanse, Gibbon

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Keratin 6 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Human KRT6 / CK6 / Cytokeratin 6

Aufreinigung: Protein G purified

Immunogen: A synthetic peptide of 11 amino acids (GSSTIKYTTTS) from the C-terminus of human Cytokeratin 6. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Horse (100%), Marmoset, Mouse, Rat, Ferret, Bat, Hamster, Elephant, Dog (91%), Sheep, Bovine (82%).

Type of Immunogen: Synthetic peptide

Klon: LHK6

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Approved: Flo (0.5 - 1 μg/10 x10⁶), IF (0.5 - 1 μg/mL), IHC, IHC-P (0.5 - 1 μg/mL)

Usage: This antibody recognizes a protein of 56  kDa, identified as cytokeratin 6 (CK6) or Keratin 6. In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Cytokeratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express Cytokeratin 6 and 16. Keratin 6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of Cytokeratin 6 is particularly associated with differentiation. ELISA: Order BSA-free antibody format for coating.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4, 0.1 mg/mL BSA, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2°C to 8°C.

Details zu Keratin 6

Target: Keratin 6 (KRT6)

Andere Bezeichnung: KRT6 / CK6 / Cytokeratin 6 (KRT6 Produkte)

Synonyme: Krt2-6 antikoerper, Krt-2.6 antikoerper, keratin 6 antikoerper, Krt6 antikoerper