ACTN3 Antikörper

Produktnummer ABIN272284

Produktdetails anti-ACTN3 Antikörper

Target: ACTN3 (Actinin, alpha 3 (ACTN3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ACTN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Spezifität: This antibody detects endogenous levels of Actinin-α3 protein. (region surrounding Glu25)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu ACTN3

Target: ACTN3 (Actinin, alpha 3 (ACTN3))

Andere Bezeichnung: alpha-Actinin-3 / ACTN3 (ACTN3 Produkte)

Synonyme: CG8953 antikoerper, Dmel\\CG8953 antikoerper, ORF1 antikoerper, acta-3 antikoerper, dabp antikoerper, ACTN2 antikoerper, actn3 antikoerper, actnl antikoerper, zgc:63559 antikoerper, fb95c03 antikoerper, wu:fb95c03 antikoerper, wu:fc11d03 antikoerper, zgc:77243 antikoerper, actinin alpha 3 (gene/pseudogene) antikoerper, actinin alpha 3 antikoerper, alpha actinin 3 antikoerper, actinin alpha 3a antikoerper, actinin alpha 3 (gene/pseudogene) L homeolog antikoerper, alpha-actinin-3 antikoerper, actinin alpha 3b antikoerper, ACTN3 antikoerper, Actn3 antikoerper, actn3a antikoerper, actn3.L antikoerper, actn3 antikoerper, LOC100439754 antikoerper, actn3b antikoerper

Hintergrund: The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and α-actinins. There are four tissue-specific α-actinins, namely α-actinin-1, α-actinin-2, α-actinin-3 and α-actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each α-actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding α-actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.Synonyms: Alpha actinin skeletal muscle isoform 3, F-actin cross-linking protein

Molekulargewicht: approx. 103 kDa

Gen-ID: 89

NCBI Accession: NP_001095

UniProt: Q08043

Pathways: Cell-Cell Junction Organization