14-3-3 theta Antikörper

Produktnummer ABIN272267

Produktdetails anti-14-3-3 theta Antikörper

Target: 14-3-3 theta (YWHAQ)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser 14-3-3 theta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of 14-3-3 θ protein. (region surrounding Gln67)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate Buffered Saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu 14-3-3 theta

Target: 14-3-3 theta (YWHAQ)

Andere Bezeichnung: 14-3-3 Protein theta (YWHAQ Produkte)

Synonyme: 14-3-3 antikoerper, 14-3-3t antikoerper, 1c5 antikoerper, hs1 antikoerper, 1C5 antikoerper, HS1 antikoerper, 2700028P07Rik antikoerper, AA409740 antikoerper, AU021156 antikoerper, R74690 antikoerper, ywhaq antikoerper, ywhaq2 antikoerper, wu:fa91b01 antikoerper, wu:fb02e12 antikoerper, wu:fb36f06 antikoerper, wu:fk86h02 antikoerper, ywhaq1 antikoerper, ywhaz antikoerper, zgc:55499 antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta S homeolog antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a antikoerper, 14-3-3 protein theta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b antikoerper, YWHAQ antikoerper, ywhaq antikoerper, Ywhaq antikoerper, ywhaq.S antikoerper, ywhaqa antikoerper, ywhaqb antikoerper

Hintergrund: 14-3-3 proteins regulate many cellular processes relevant to cancer biology,notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activitiesSynonyms: 14-3-3 protein T-cell, 14-3-3 protein tau, Protein HS1, YWHAQ

Molekulargewicht: approx. 28 kDa

Gen-ID: 10971

NCBI Accession: NP_006817

UniProt: P27348

Pathways: Apoptose, Myometrial Relaxation and Contraction