TINF2 Antikörper

Produktnummer ABIN272251

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TINF2 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TINF2 Antikörper (ABIN272251)

Target: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TINF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TINF2 Antikörper

Spezifität: This antibody detects endogenous levels of TIN2 protein. (region surrounding Val94)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu TINF2

Target: TINF2 (TIN2) (TERF1 Interacting Nuclear Factor 2 (TIN2))

Andere Bezeichnung: TINF2 / TIN2

Hintergrund: Telomeres are DNA-protein structures that protect the ends of linear chromosomes and help maintain genomic stability and cell phenotype. Mammalian telomeric proteins consist of TRF1 (telomeric repeat binding factor), TRF2, tankyrase, and TIN2, which have no recognized orthologs in the budding yeast, Saccharomyces cerevisiae, and RAP1, which is an ortholog to the yeast telomeric protein scRap1. Like scRap1, mammalian RAP1 regulates telomere elongation. RAP1 interacts with two proteins, Rif1 and Rif2, which contribute to telomere length homeostasis. Unlike scRap1, which binds telomeric DNA directly, RAP1 is recruited to telomeres by TRF2. The functional and structural similarities of scRap1 to mammalian RAP1 suggest that the budding yeast preserved RAP1 at telomeres, but lost the TRF component. The telomeric protein TRF1 requires TIN2 to control telomere length in human cells.Synonyms: TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2

Molekulargewicht: approx. 53 kDa

Gen-ID: 26277

NCBI Accession: NP_001092744

UniProt: Q9BSI4

Pathways: Zellzyklus, Telomere Maintenance, Regulation of Carbohydrate Metabolic Process