PIAS1
Reaktivität: Human
WB, IHC, ELISA
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA: 1: 10000approx. 1: 20000. Western blot: 1: 500approx. 1: 1000. Immunohistochemistry on paraffin sections: 1: 50approx. 1: 200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
2900068C24Rik antikoerper, Ddxbp1 antikoerper, GBP antikoerper, DDXBP1 antikoerper, GU/RH-II antikoerper, ZMIZ3 antikoerper, ddxbp1 antikoerper, gbp antikoerper, pias antikoerper, pias1-A antikoerper, xPAIS1 antikoerper, xPIAS1 antikoerper, zmiz3 antikoerper, protein inhibitor of activated STAT 1 antikoerper, protein inhibitor of activated STAT, 1 antikoerper, protein inhibitor of activated STAT, 1a antikoerper, protein inhibitor of activated STAT 1 L homeolog antikoerper, PIAS1 antikoerper, Pias1 antikoerper, pias1a antikoerper, pias1.L antikoerper
Hintergrund
The IL-6-type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.Synonyms: DDXBP1, DEAD/H box-binding protein 1, E3 SUMO-protein ligase PIAS1, Gu-binding protein, PIAS-1, Protein inhibitor of activated STAT protein 1, RNA helicase II-binding protein