UBR5 Antikörper

Produktnummer ABIN271946

Produktdetails anti-UBR5 Antikörper

Target: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of EDD protein. (region surrounding Thr14)

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu UBR5

Target: UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))

Andere Bezeichnung: UBR5 / HYD (UBR5 Produkte)

Synonyme: DD5 antikoerper, EDD antikoerper, EDD1 antikoerper, HYD antikoerper, 4432411E13Rik antikoerper, AW549941 antikoerper, C77315 antikoerper, D030042K14 antikoerper, Edd antikoerper, Edd1 antikoerper, mKIAA0896 antikoerper, Dd5 antikoerper, Rat100 antikoerper, ubiquitin protein ligase E3 component n-recognin 5 antikoerper, UBR5 antikoerper, Ubr5 antikoerper

Hintergrund: EDD (for E3 identified by Differential Display) is a progestin-regulated gene that was isolated from T-47D human breast cancer cells. Based on sequence homology, EDD appears to be a human homolog of the Drosophila hyperplastic discs (hyd) gene, a tumor suppressor gene that is required for control of imaginal disc growth (2). EDD contains a HECT domain in the carboxy terminus. HECT domain-containing proteins function as ubiquitin-protein ligases, or E3 enzymes. EDD has been shown to bind to ubiquitin, and like other HECT family proteins, may function as an E3 ubiquitin-protein ligase.Synonyms: E3 ubiquitin-protein ligase, E3 ubiquitin-protein ligase UBR5, EDD, EDD1, HECT domain-containing 1, Hyperplastic discs protein homolog, KIAA0896

Molekulargewicht: approx. 309 kDa

Gen-ID: 51366

NCBI Accession: NP_056986

UniProt: O95071

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway