Disialoganglioside 2 (GD2) Antikörper

Produktnummer ABIN2689490

Dieser Maus Monoklonal Antikörper detektiert spezifisch Disialoganglioside 2 in FACS, CyTox, IHC (fro) und IF. Es zeigt Reaktivität gegenüber Proben von Human und Maus. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für Disialoganglioside 2 (GD2) Antikörper (ABIN2689490)

Target: Disialoganglioside 2 (GD2)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Flow Cytometry (FACS), Cytotoxicity Test (CyTox), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Klon: 14-G2a

Produktdetails

Produktmerkmale: Gangliosides are sialic-acid bearing glycolipids that are expressed on the surface of all mammalian cells, and are likely involved in mediating cell-substratum interactions. They are important target antigens for antibody dependent cellular cytotoxicity (ADCC) of human melanoma and neuroblastoma cells. Human melanoma cells produce gangliosides, designated as GD2 and GD3 which are deposited in the subtratum-attached material, and may play a significant role in the melanoma metastatic phenotype.

BD Pharmingen™ Purified Mouse Anti-Human Disialoganglioside GD2 - Purified - Clone 14.G2a - Isotype Mouse IgG2a - Reactivity Hu, Ms - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: LAN-1 human neuroblastoma cells

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen

Frost, Hank, Reaman, Frierdich, Seeger, Gan, Anderson, Ettinger, Cairo, Blazar, Krailo, Matthay, Reisfeld, Sondel: "A phase I/IB trial of murine monoclonal anti-GD2 antibody 14.G2a plus interleukin-2 in children with refractory neuroblastoma: a report of the Children's Cancer Group." in: Cancer, Vol. 80, Issue 2, pp. 317-33, (1997) (PubMed).

Cheresh, Pierschbacher, Herzig, Mujoo: "Disialogangliosides GD2 and GD3 are involved in the attachment of human melanoma and neuroblastoma cells to extracellular matrix proteins." in: The Journal of cell biology, Vol. 102, Issue 3, pp. 688-96, (1986) (PubMed).

Cheresh, Rosenberg, Mujoo, Hirschowitz, Reisfeld: "Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis." in: Cancer research, Vol. 46, Issue 10, pp. 5112-8, (1986) (PubMed).

Cheresh, Honsik, Staffileno, Jung, Reisfeld: "Disialoganglioside GD3 on human melanoma serves as a relevant target antigen for monoclonal antibody-mediated tumor cytolysis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 5155-9, (1985) (PubMed).

Hakomori: "Tumor-associated carbohydrate antigens." in: Annual review of immunology, Vol. 2, pp. 103-26, (1985) (PubMed).

Antigendetails

Target: Disialoganglioside 2 (GD2)

Andere Bezeichnung: Disialoganglioside GD2

Hintergrund: Synonyms: GD2