Transferrin Receptor Antikörper (Biotin)

Produktnummer ABIN2689388

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch Transferrin Receptor in FACS. Er zeigt eine Reaktivität gegenüber Maus und wurde in 1 Publikation erwähnt.

Kurzübersicht für Transferrin Receptor Antikörper (Biotin) (ABIN2689388)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Receptor Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: C2

Produktdetails anti-Transferrin Receptor Antikörper (Biotin)

Marke: BD Pharmingen™

Produktmerkmale: The C2 antibody reacts with the transferrin receptor CD71, a disulfide-linked homodimer of 95- kDa subunits. CD71 mediates one of the cellular mechanisms for iron uptake, and its expression is regulated according to the cell's iron requirements. It is expressed at high levels on developing erythroid cells, and it is upregulated after mitogenic activation of B or T lymphocytes. C2 mAb selectivity inhibits some types of T- and B-cell activation by down-regulation of transferrin receptor expression, but it does not block binding of transferrin. Although the isotype of C2 mAb was originally reported to be Rat IgG2a, further investigations have demonstrated that it is Rat IgG1, κ. Two-color analysis of the expression of CD71 on developing erythroid cells. BALB/c bone-marrow leukocytes were simultaneously stained with PE-conjugated anti-mouse Erythroid Cells mAb TER-119 (Cat. no. 553673) and biotinylated mAb C2 (Right panel), followed by Avidin-FITC (Cat. no. 554057). Flow cytometry was performed on a BD FACScan™ flow cytometry system.

BD Pharmingen™ Biotin Rat Anti-Mouse CD71 - Biotin - Clone C2 (also known as C2F2) - Isotype Rat IgG1, κ - Reactivity Ms - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse cell line

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-Transferrin Receptor Antikörper (Biotin) (ABIN2689388)

Lok, Loh: "Regulation of transferrin function and expression: review and update." in: Biological signals and receptors, Vol. 7, Issue 3, pp. 157-78, (1998) (PubMed).

Details zu Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung: CD71

Hintergrund: Synonyms: Transferrin Receptor

Pathways: Transition Metal Ion Homeostasis