F11R Antikörper

Produktnummer ABIN2689190

Dieses Maus Monoklonal-Antikörper erkennt spezifisch F11R in FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für F11R Antikörper (ABIN2689190)

Target: F11R (F11 Receptor (F11R))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser F11R Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: M-Ab-F11

Produktdetails anti-F11R Antikörper

Marke: BD Pharmingen™

Produktmerkmale: The M.Ab.F11 monoclonal antibody specifically binds to CD321 which is also known as JAM-1 (Junctional adhesion molecule 1), Junctional adhesion molecule A (JAM-A), and F11 Receptor (F11R). CD321 is a 32-35 kDa type I transmembrane glycoprotein that includes two extracellular immunoglobulin-like domains. CD321 is expressed on platelets, leucocytes, red blood cells, endothelial cells, epithelial cells, and various cell lines. CD321 functions as an adhesion receptor molecule on platelets. It also supports the tight junction formation between endothelial cells, where it may regulate the transendothelial migration of leucocytes, and epithelial cells. M.Ab.F11 is a stimulatory antibody that can induce morphological changes, granule secretion, and aggregation in human platelets. Flow cytometric analysis of human CD321 staining on platelets. Peripheral blood platelets were stained with either Purified Mouse Anti-Human CD321 (JAM-1) (Cat. No. 552147, solid line histogram) or Purified Mouse IgG1, κ Isotype Control (Cat. No. 555746, dashed line histogram), followed by second step staining with FITC Goat Anti-Mouse IgG/IgM (Cat. No. 555988).

BD Pharmingen™ Purified Mouse Anti-Human CD321 (JAM-1) - Purified - Clone M.Ab.F11 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-F11R Antikörper (ABIN2689190)

Florian, Sonneck, Czerny, Hennersdorf, Hauswirth, Bühring, Valent: "Detection of novel leukocyte differentiation antigens on basophils and mast cells by HLDA8 antibodies." in: Allergy, Vol. 61, Issue 9, pp. 1054-62, (2006) (PubMed).

Horváth, Drbel, Angelisová, Hilgert, Horejsí: "Non-lineage antigens: section report." in: Cellular immunology, Vol. 236, Issue 1-2, pp. 42-7, (2005) (PubMed).

Babinska, Kedees, Athar, Sobocki, Sobocka, Ahmed, Ehrlich, Hussain, Kornecki: "Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion." in: Thrombosis and haemostasis, Vol. 87, Issue 4, pp. 712-21, (2002) (PubMed).

Sobocka, Sobocki, Banerjee, Weiss, Rushbrook, Norin, Hartwig, Salifu, Markell, Babinska, Ehrlich, Kornecki: "Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation." in: Blood, Vol. 95, Issue 8, pp. 2600-9, (2000) (PubMed).

Kornecki, Walkowiak, Naik, Ehrlich: "Activation of human platelets by a stimulatory monoclonal antibody." in: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 10042-8, (1990) (PubMed).

Details zu F11R

Target: F11R (F11 Receptor (F11R))

Andere Bezeichnung: CD321 JAM-1

Hintergrund: Synonyms: JAM-1, Platelet F11 receptor, F11R, JAM-A, PAM-1

Pathways: Cell-Cell Junction Organization