VCAM1 Antikörper (Vascular Cell Adhesion Molecule 1) (Biotin)

Details for Product anti-VCAM1 Antibody No. ABIN2688883, Anbieter: Anmelden zum Anzeigen
Antigen
  • CD106
  • INCAM-100
  • Vcam-1
  • VCAM1B
  • fi76d06
  • wu:fi76d06
  • zgc:158875
  • VCAM1
  • vascular cell adhesion molecule 1
  • vascular cell adhesion molecule 1b
  • VCAM1
  • Vcam1
  • vcam1b
  • VCAM-1
Reaktivität
Maus
451
208
85
33
11
9
8
3
1
Wirt
Ratte
351
159
125
16
14
8
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser VCAM1 Antikörper ist konjugiert mit Biotin
67
59
55
20
12
9
9
6
6
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Applikation
Flow Cytometry (FACS)
387
241
211
158
143
107
63
46
43
26
26
24
17
13
10
5
4
3
3
3
2
2
2
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Marke BD Pharmingen™
Immunogen Mouse preadipose cell line PA6
Klon 429
Isotyp IgG2a, kappa
Produktmerkmale The 429 antibody reacts with both the long (~110 kDa) transmembrane-spanning form and the truncated (~47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 (α4β1 integrin) and LPAM-1 (α4β7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was mouse preadipose cell line PA6.

BD Pharmingen™ Biotin Rat Anti-Mouse CD106 - Biotin - Clone 429 (MVCAM.A) - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Plasmids, Primers & others Plasmide, Primers & weitere VCAM1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung CD106 (VCAM1 Antibody Abstract)
Hintergrund Synonyms: VCAM-1
Pathways Carbohydrate Homeostasis
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 0.5 mg/mL
Buffer Aqueous buffered solution containing ≤0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung The antibody was conjugated with biotin under optimum conditions, and unreacted biotin was removed.
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Produkt verwendet in: Koni, Joshi, Temann, Olson, Burkly, Flavell: "Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow." in: The Journal of experimental medicine, Vol. 193, Issue 6, pp. 741-54, 2001 (PubMed).

Ishiyama, Kitagawa, Takahashi, Kina, Hirokawa: "Expression of VCAM-1 in lymphocytes during the process of apoptosis." in: Pathobiology : journal of immunopathology, molecular and cellular biology, Vol. 66, Issue 6, pp. 274-83, 1998 (PubMed).

Kinashi, Springer: "Adhesion molecules in hematopoietic cells." in: Blood cells, Vol. 20, Issue 1, pp. 25-44, 1995 (PubMed).

Kinashi, St Pierre, Springer: "Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells." in: Journal of leukocyte biology, Vol. 57, Issue 1, pp. 168-73, 1995 (PubMed).

Baron, Reich, Visintin, Janeway: "The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1." in: The Journal of clinical investigation, Vol. 93, Issue 4, pp. 1700-8, 1994 (PubMed).

Bevilacqua: "Endothelial-leukocyte adhesion molecules." in: Annual review of immunology, Vol. 11, Issue 4, pp. 767-804, 1993 (PubMed).

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