VCAM1 Antikörper

Produktnummer ABIN2688881

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch VCAM1 in FACS, IP, IF, IHC (fro) und BR. Er zeigt eine Reaktivität gegenüber Maus und wurde in 7+ Publikationen erwähnt.

Kurzübersicht für VCAM1 Antikörper (ABIN2688881)

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser VCAM1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)

Klon: 429

Produktdetails anti-VCAM1 Antikörper

Marke: BD Pharmingen™

Produktmerkmale: The 429 antibody reacts with both the long (~110 kDa) transmembrane-spanning form and the truncated (~47 kDa) GPI-linked form of vascular cell adhesion molecule-1 (VCAM-1, CD106). CD106 is constitutively expressed on bone marrow stromal cells, myeloid cells, and splenic dendritic cells. Its expression on endothelial cells is upregulated by inflammatory cytokines and in certain pathologic conditions. CD106 expression has also been detected on apoptotic thymocytes, splenocytes, and lymphoid cell lines. VCAM-1 is a counter-receptor for VLA-4 (α4β1 integrin) and LPAM-1 (α4β7 integrin), and the 429 antibody partially blocks VCAM-1-mediated binding functions. Source of the immunogen was mouse preadipose cell line PA6.

BD Pharmingen™ Purified Rat Anti-Mouse CD106 - Purified - Clone 429 (MVCAM.A) - Isotype Rat IgG2a, κ - Reactivity Ms - 0.5 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse preadipose cell line PA6

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-VCAM1 Antikörper (ABIN2688881)

Koni, Joshi, Temann, Olson, Burkly, Flavell: "Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow." in: The Journal of experimental medicine, Vol. 193, Issue 6, pp. 741-54, (2001) (PubMed).

Ishiyama, Kitagawa, Takahashi, Kina, Hirokawa: "Expression of VCAM-1 in lymphocytes during the process of apoptosis." in: Pathobiology : journal of immunopathology, molecular and cellular biology, Vol. 66, Issue 6, pp. 274-83, (1998) (PubMed).

Buck, Edelman, Buck, Kennedy, Baldwin: "Expression patterns of adhesion receptors in the developing mouse lung: functional implications." in: Cell adhesion and communication, Vol. 4, Issue 2, pp. 69-87, (1997) (PubMed).

Kinashi, Springer: "Adhesion molecules in hematopoietic cells." in: Blood cells, Vol. 20, Issue 1, pp. 25-44, (1995) (PubMed).

Kinashi, St Pierre, Springer: "Expression of glycophosphatidylinositol-anchored and -non-anchored isoforms of vascular cell adhesion molecule 1 in murine stromal and endothelial cells." in: Journal of leukocyte biology, Vol. 57, Issue 1, pp. 168-73, (1995) (PubMed).

Baron, Reich, Visintin, Janeway: "The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1." in: The Journal of clinical investigation, Vol. 93, Issue 4, pp. 1700-8, (1994) (PubMed).

Bevilacqua: "Endothelial-leukocyte adhesion molecules." in: Annual review of immunology, Vol. 11, Issue 4, pp. 767-804, (1993) (PubMed).

Details zu VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Andere Bezeichnung: CD106

Hintergrund: Synonyms: VCAM-1

Pathways: Carbohydrate Homeostasis