RBPJ Antikörper

Produktnummer ABIN2668822

Es gibt 1 Publikation für dieses Produkt. Der Ratte Monoklonal anti-RBPJ Antikörper wird verwendet zum Nachweis von RBPJ in Proben von Human und Maus. Er wurde validiert für IF, ICC, ChIP und SSA.

Kurzübersicht für RBPJ Antikörper (ABIN2668822)

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser RBPJ Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunocytochemistry (ICC), Chromatin Immunoprecipitation (ChIP), Supershift Assay (SSA)

Klon: 1F1

Produktdetails anti-RBPJ Antikörper

Verwendungszweck: RBPJ antibody (mAb) (Clone 1F1)

Aufreinigung: Protein G Chromatography

Immunogen: This antibody was raised against a full-length recombinant protein corresponding to human RBPJ.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ICC/IF: 0.5 μg/mL dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Referenzen für anti-RBPJ Antikörper (ABIN2668822)

Ehm, Göritz, Covic, Schäffner, Schwarz, Karaca, Kempkes, Kremmer, Pfrieger, Espinosa, Bigas, Giachino, Taylor, Frisén, Lie: "RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 41, pp. 13794-807, (2010) (PubMed).

Details zu RBPJ

Target: RBPJ (Recombination Signal Binding Protein For Immunoglobulin kappa J Region (RBPJ))

Andere Bezeichnung: RBPJ

Hintergrund: RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA.

Molekulargewicht: 68 kDa

Gen-ID: 3516

NCBI Accession: NP_056958

Pathways: Notch Signalweg, Stem Cell Maintenance, Smooth Muscle Cell Migration