PRKDC Antikörper (phosphorylated)
Kurzübersicht für PRKDC Antikörper (phosphorylated) (ABIN2666330)
Target
Alle PRKDC Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- phosphorylated
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Kreuzreaktivität (Details)
- reacts with Thr2609-phosphorylated DNA-PKcs
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Aufreinigung
- The antibody was purified by affinity chromatography.
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Isotyp
- IgG1 kappa
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anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibody
PRKDC Reaktivität: Human ELISA, IHC, ICC Wirt: Maus Monoclonal 3H6 unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4019-4128) antibodyPRKDC Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 1B9 unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) antibodyPRKDC Reaktivität: Human WB, IHC, IP, ICC Wirt: Maus Monoclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibodyPRKDC Reaktivität: Human, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibodyPRKDC Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 3899-4128) antibodyPRKDC Reaktivität: Maus WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (C-Term) antibodyPRKDC Reaktivität: Human, Maus WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 151-300) antibodyPRKDC Reaktivität: Human, Ratte WB, ELISA, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4075-4104), (C-Term) antibodyPRKDC Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB3465-3466 unconjugated
anti-Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC) (AA 4019-4129) antibodyPRKDC Reaktivität: Human WB, ELISA, IHC, IHC (p) Wirt: Maus Monoclonal 2A8 unconjugated
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 0.5 mg/mL
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Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Informationen zur Lagerung
- Upon receipt, store undiluted between 2°C and 8°C.
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- PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))
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Andere Bezeichnung
- DNA-PKcs
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Hintergrund
- DNA-protein kinase catalytic subunit (DNA-PKcs) also known as DNA-activated kinase is a nuclear 460-470 kD serine threonine kinase involved in double-stranded DNA break repair, VDJ recombination, and transcriptional modulation. DNA-PKcs must bind DNA ends to become active. DNA-PKcs is modified by phosphorylation and has been shown to interact with Ku70/Ku80, KIP, DNA-ligase IV, and XRCC4 proteins. Phosphorylated DNA-PKcs is upregulated after DNA damaage. The 10B1 monoclonal antibody recognizes phosphorylated human DNA-PKcs (Thr2609) and has been shown to be useful for immunofluorescence staining and Western blotting.
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Pathways
- DNA Reparatur, Production of Molecular Mediator of Immune Response
Target
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