BID Antikörper
Kurzübersicht für BID Antikörper (ABIN2666317)
Target
Alle BID Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Aufreinigung
- The antibody was purified by affinity chromatography.
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Isotyp
- IgG1
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 0.5 mg/mL
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Buffer
- phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.
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Lagerung
- 4 °C
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Informationen zur Lagerung
- Upon receipt, store undiluted between 2°C and 8°C.
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- BID (BH3 Interacting Domain Death Agonist (BID))
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Andere Bezeichnung
- BID
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Hintergrund
- BID, a BH3 interacting domain death agonist is a member of the Bcl-2/Bcl-xL family. BID can form a heterodimer with either agonist BAX or antagonist Bcl-2. It is a mediator of mitochondrial damage induced by Caspase-8 (CASP8). After the cleavage by CASP8, the COOH-terminal part translocates to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
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Pathways
- Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity
Target
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