IRF1 Antikörper
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- Target Alle IRF1 Antikörper anzeigen
- IRF1 (Interferon Regulatory Factor 1 (IRF1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser IRF1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Aufreinigung
- Affinity purified.
- Klon
- 13H3A44
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product IRF1 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Upon receipt, store undiluted at 4°C.
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- Target
- IRF1 (Interferon Regulatory Factor 1 (IRF1))
- Andere Bezeichnung
- IRF1 (IRF1 Produkte)
- Synonyme
- irf1 antikoerper, zgc:136945 antikoerper, IRF1 antikoerper, irf11 antikoerper, zgc:103566 antikoerper, IRF-1 antikoerper, MAR antikoerper, AU020929 antikoerper, Irf-1 antikoerper, interferon regulatory factor 1 antikoerper, interferon regulatory factor 1a antikoerper, interferon regulatory factor 1b antikoerper, IRF1 antikoerper, irf1a antikoerper, irf1b antikoerper, Irf1 antikoerper
- Hintergrund
- IRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters.
- Pathways
- Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagie
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