NLRP12 Antikörper
Kurzübersicht für NLRP12 Antikörper (ABIN2665297)
Target
Alle NLRP12 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Aufreinigung
- The antibody was purified by affinity chromatography.
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Isotyp
- IgG2b kappa
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anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 183-212), (N-Term) antibody
NLRP12 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB33963 unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 1-110) antibodyNLRP12 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 4B9 unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (Internal Region) antibodyVerified NLRP12 Reaktivität: Maus WB, ELISA Wirt: Ziege Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 862-1062) antibodyNLRP12 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) antibodyNLRP12 Reaktivität: Human, Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 12 (NLRP12) (AA 183-212) antibodyNLRP12 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 0.5 mg/mL
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Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Informationen zur Lagerung
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- NLRP12 (NLR Family, Pyrin Domain Containing 12 (NLRP12))
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Andere Bezeichnung
- NLRP12
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Hintergrund
- NLRP12, a member of the Nod-like receptor (NLR) family of proteins, was originally suggested to act as an inflammasome forming component and a modulator of NF-κB signaling. Recent studies revealed that NLRP12 plays anti-inflammatory roles, as NLRP12-deficient mice are more susceptible to chemically induced colitis, and show a more severe infiltration of granulocytes and T cells. The colitis induced in NLRP12-/- mice is associated with increased production of proinflammatory cytokines and activation of both NF-κB and ERK signaling pathways. NLRP12 was reported to attenuate canonical NF-κB signaling by inhibiting IRAK-1 phosphorylation. NLRP12 also down-regulates non-canonical NF-κB signaling through interaction with TRAF3 and the NF-κB inducing kinase NIK.
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Pathways
- Positive Regulation of Endopeptidase Activity, Inflammasome
Target
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