M-CSF/CSF1 Antikörper

Produktnummer ABIN2665252

Produktdetails anti-M-CSF/CSF1 Antikörper

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser M-CSF/CSF1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: L1617F1

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu M-CSF/CSF1

Target: M-CSF/CSF1 (CSF1) (Colony Stimulating Factor 1 (Macrophage) (CSF1))

Andere Bezeichnung: M-CSF (CSF1 Produkte)

Synonyme: CSF-1 antikoerper, MCSF antikoerper, C87615 antikoerper, Csfm antikoerper, op antikoerper, csf1-1 antikoerper, zgc:172186 antikoerper, CSF1 antikoerper, csf1-2 antikoerper, zgc:158436 antikoerper, colony stimulating factor 1 antikoerper, colony stimulating factor 1 (macrophage) antikoerper, colony stimulating factor 1a (macrophage) antikoerper, macrophage colony-stimulating factor 1 antikoerper, macrophage colony stimulating factor antikoerper, colony stimulating factor 1b (macrophage) antikoerper, CSF1 antikoerper, Csf1 antikoerper, csf1a antikoerper, LOC396599 antikoerper, LOC100860895 antikoerper, csf1b antikoerper

Hintergrund: M-CSF is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer. M-CSF is released by fibroblasts, breast cancer cell lines, alveolar macrophages, stromal bone marrow cells, endothelial cells, and mesenchymal cells. It binds CD14+ monocytes and promotes the survival/proliferation of human peripheral blood monocytes. In addition, M-CSF enhances inducible monocyte functions including phagocytic activity, microbial killing, cytotoxicity for tumor cells as well as synthesis of inflammatory cytokines such as IL-1, TNF-α, and IFN-γ in monocytes. M-CSF induces RANKL production in mature human osteoclasts and, consequently, this makes M-CSF a potent stimulator of mature osteoclast resorbing activity. Also, M-CSF induces VEGF production in human monocytes and human tumor cells. High levels of M-CSF, mononuclear phagocytes, and VEGF are associated with poor prognosis in patients with cancer.

Pathways: RTK Signalweg