JAG2 Antikörper

Produktnummer ABIN2665211

Dieses Anti-JAG2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von JAG2 in FACS. Geeignet für Human.

Kurzübersicht für JAG2 Antikörper (ABIN2665211)

Target: JAG2 (Jagged 2 (JAG2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser JAG2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: MHJ2-523

Produktdetails anti-JAG2 Antikörper

Aufreinigung: The antibody was purified by affinity chromatography.

Isotyp: IgG1 kappa, IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu JAG2

Target: JAG2 (Jagged 2 (JAG2))

Andere Bezeichnung: Jagged 2

Hintergrund: The binding of Notch ligands with their receptors results in the proteolysis of Notch and movement of intracellular portion of Notch into the nucleus. This translocation triggers a series of signaling process. The Notch receptors and their ligands are highly conserved signaling molecules throughout development. They regulate cell fate decision for various cell developments, including myogenesis, neurogenesis, and lymphocyte development. There is growing evidence that signals transmitted through different Notch ligands can differentially affect target cells. The Jagged-2 is one of the several Notch ligands identified. It is a single pass transmembrane protein consisting of a large extracellular N-terminal which includes the DSL (Delta-Serrate-Lag-2) domain, followed by a tandem array of EGF-like repeats (ELRs) and cysteine-rich domain (CRD). Jagged 2 is expressed on lymphoma cells and some other tumor cells. Jagged-2 is reported to be essential for the regulation of spermatogenesis. Notch1/Jagged-2 signaling system plays an important role for male germ cells to differentiate, T cells and B cells to differentiate.

Pathways: Notch Signalweg, Sensory Perception of Sound