EPO Antikörper

Produktnummer ABIN2664955

Produktdetails anti-EPO Antikörper

Target: EPO (Erythropoietin (EPO))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EPO Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: M0312E3

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu EPO

Target: EPO (Erythropoietin (EPO))

Andere Bezeichnung: EPO (EPO Produkte)

Substanzklasse: Hormone

Hintergrund: EPO is the major regulator of differentiation, proliferation, and survival of erythroid progenitors. Hypoxia induces erythropoiesis which causes cells to produce hypoxia inducible factor (HIF) that is directly involved in EPO expression. HIF-Prolyl hydroxylase (HIF-PH) is a sensor of levels of iron, oxygen, and metabolic activity. High levels of HIF protein induce EPO production in the kidneys and liver, and mobilize iron to support erythropoiesis. EPO has been used in the treatment of anemia associated with a number of conditions, such as chronic kidney disease, cancer patients on chemotherapy, and antiviral HIV therapy.

Pathways: JAK-STAT Signalweg, Hormone Activity, Negative Regulation of intrinsic apoptotic Signaling, Negative Regulation of Transporter Activity