CCRL1 Antikörper

Produktnummer ABIN2664103

Produktdetails anti-CCRL1 Antikörper

Target: CCRL1 (Chemokine (C-C Motif) Receptor-Like 1 (CCRL1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCRL1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Intracellular Flow Cytometry (ICFC)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 13E11

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CCRL1

Target: CCRL1 (Chemokine (C-C Motif) Receptor-Like 1 (CCRL1))

Andere Bezeichnung: CCX-CKR (CCRL1 Produkte)

Synonyme: CC-CKR-11 antikoerper, CCBP2 antikoerper, CCR-11 antikoerper, CCR10 antikoerper, CCR11 antikoerper, CCRL1 antikoerper, CCX CKR antikoerper, CCX-CKR antikoerper, CKR-11 antikoerper, PPR1 antikoerper, VSHK1 antikoerper, A630091E18Rik antikoerper, CCX-CKR1 antikoerper, Ccrl1 antikoerper, Cmkbrl1 antikoerper, atypical chemokine receptor 4 antikoerper, chemokine (C-C motif) receptor-like 1 antikoerper, Chemokine receptor-like 1 antikoerper, chemerin chemokine-like receptor 1 antikoerper, ACKR4 antikoerper, Ackr4 antikoerper, CCRL1 antikoerper, cml1 antikoerper, CMKLR1 antikoerper

Hintergrund: Human CCX-CKR, also known as CCRL1, is a 40 kD, G-protein-coupled, seven transmembrane receptor. CCRL1 is a decoy receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25 that regulates chemotaxis of lymphocytes and cancer cells. Chemokine binding by CCX-CKR causes its internalization, reducing levels of available chemokine, and thus regulating migration of lymphocytes and cancerous cells. CCX-CKR is expressed by stromal cells of skin-draining lymph nodes, thymic epithelial cells, and immature dendritic cells (DCs). A low CCX-CKR expression in tumor cells correlates with a poor survival rate of breast cancer patients.