CCL28 Antikörper

Produktnummer ABIN2664098

Produktdetails anti-CCL28 Antikörper

Target: CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CCL28 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Cytometry by Time of Flight (CyTOF)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: J132C3

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu CCL28

Target: CCL28 (Chemokine (C-C Motif) Ligand 28 (CCL28))

Andere Bezeichnung: CCL28 (CCL28 Produkte)

Synonyme: Scya28 antikoerper, CCL28 antikoerper, ccl28 antikoerper, nrpb antikoerper, enc-1 antikoerper, pig10 antikoerper, Encr-3 antikoerper, klhl35 antikoerper, Xencr-3 antikoerper, tp53i10 antikoerper, LOC100303767 antikoerper, CCK1 antikoerper, MEC antikoerper, SCYA28 antikoerper, C-C motif chemokine ligand 28 antikoerper, ectodermal-neural cortex 1 (with BTB domain) antikoerper, C-C motif chemokine 28 antikoerper, chemokine (C-C motif) ligand 28 antikoerper, Ccl28 antikoerper, CCL28 antikoerper, ccl28 antikoerper, enc1 antikoerper, LOC100303767 antikoerper

Hintergrund: Human CCL28 was identified in an EST database using a human chemokine consensus sequence. CCL28 is constitutively expressed by mucosal epithelial cells such as exocrine glands, trachea, and colon. Acinar epithelial cells in human and mouse salivary glands are strongly positive for CCL28 by immunostaining, and human saliva and milk contain high concentrations of CCL28. Furthermore, it is known that human and mouse CCL28 have antimicrobial activity attributed to the C-terminus of CCL28 against Candida albicans, Gram-negative bacteria, and Gram-positive bacteria. In addition, using a CCR10 deficient mouse model, it was shown that CCR10 plays a critical role in localization and accumulation of IgA ASC in lactating mammary glands. Also, it has been described that CCL28 is upregulated in epithelial inflammation, and this upregulation allows the recruitment of Tregs expressing CCR10. In fact, a subpopulation of CCR10-expressing CD25+CD4+FOXP3+ Tregs with potent anti-inflammatory properties was isolated from a chronically inflamed human liver. Information suggests that tumor hypoxia promotes the recruitment of Tregs through induction of expression of CCL28, and this induction is mediated by the hypoxia inducible factor-1α (HIF-1α). Therefore, tumor hypoxia promotes tolerance and angiogenesis via CCL28 and Tregs.