CEBPA Antikörper
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- Target Alle CEBPA Antikörper anzeigen
- CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CEBPA Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Kreuzreaktivität
- Maus
- Kreuzreaktivität (Details)
- weakly cross-reacts with mouse
- Aufreinigung
- The antibody was purified by affinity chromatography.
- Klon
- 16C12B70
- Isotyp
- IgG2a kappa
- Top Product
- Discover our top product CEBPA Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- The antibody solution should be stored undiluted between 2°C and 8°C.
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- Target
- CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))
- Andere Bezeichnung
- C/EBPalpha (CEBPA Produkte)
- Hintergrund
- The CCAAT-enhancer binding proteins (C/EBP) are members of the basic region/leucine zipper (bZIP) transcription factors, that bind to the consensus CCAAT sequence in DNA. C/EBPα is expressed in two isoforms: p42 and p30 by ultilizing different translational start codons. The C/EBPα p30 isoform has little to no transactivating activity and acts as an inhibitor. C/EBPα regulates expression of various myeloid-specific genes and is required for myeloid differentiation. C/EBPα has been found to play a key role in adipogenesis, since inhibition of C/EBPα blocks adipocyte differentiation. C/EBPα also regulates cell cycle progression through interactions with cyclin-dependent kinases (CDK) and by inducing the expression of CDK inhibitor p21. Mutations in the C/EBPα gene are associated with the development of acute myeloid leukemia.
- Pathways
- Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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