SIRPA Antikörper (PE)

Produktnummer ABIN2663092

Der Maus Monoklonal anti-SIRPA Antikörper wird verwendet zum Nachweis von SIRPA in Proben von Ratte. Er wurde validiert für FACS, IP und BR.

Kurzübersicht für SIRPA Antikörper (PE) (ABIN2663092)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SIRPA Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Blocking Reagent (BR)

Klon: OX-41

Produktdetails anti-SIRPA Antikörper (PE)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.5 % BSA (origin U.S.)

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: CD172a

Hintergrund: Rat CD172a, also known as a signal-regulatory protein α (SIRPα), is a 75-110 kD transmembrane glycoprotein involved in the receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily primarily expressed on monocytes/macrophages, granulocytes, dendritic cells and neurons. CD172a serves as a substrate of activated receptor ttyrosine kinases (RTKs). The interaction of the CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion and phagocytosis. CD47 (IAP) is an extracellular ligand for CD172a.