DDR1 Antikörper (PE)

Produktnummer ABIN2663088

Dieses Maus Monoklonal-Antikörper erkennt spezifisch DDR1 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DDR1 Antikörper (PE) (ABIN2663088)

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DDR1 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: 51D6

Produktdetails anti-DDR1 Antikörper (PE)

Produktmerkmale: The 51D6 monclonal antibody recognizes human CD167a also known as discoidin domain receptor, DDR1, neuroepithelial tyrosine kinase, epithelial-specific receptor kinase, tyrosine kinase receptor E (trkE), cell adhesion kinase (CAK), PTK3, and RTK6. CD167a is a membrane type II receptor kinase, containing a factor VIII-like domain. At least five isoforms are generated through alternative splicing of the kinase domain of human DDR1 gene. These isoforms are named wtih suffixes a to e. CD167a is expressed on epithelial cells, keratinocytes, leukocytes, monocytes and has been reported to be overexpressed in some breast carcinomas. CD167a expression can be upregulated by p53. CD167a has been reported to interact with a variety of proteins including collagen type II alpha 1, collagen type III alpha 1, collagen type V alpha 2, collagen type XI alpha 1, phospholipase gamma 1, SHC, and the lipid-anchored docking protein FRS2. CD167a can be phosphorylated on Y513. Animal studies suggest that CD167a is involved in arterial wound healing. The 51D6 antibody has been shown to be useful for flow cytometric detection of human CD167a as well as immunoprecipitation.

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Isotyp: IgG3 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu DDR1

Target: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Andere Bezeichnung: CD167a

Pathways: RTK Signalweg, Smooth Muscle Cell Migration