SIRPA Antikörper (FITC)

Produktnummer ABIN2661533

Dieses Anti-SIRPA-Antikörper ist ein Ratte Monoklonal-Antikörper zur Detektion von SIRPA in ELISA, IHC, ICFC und CyTOF. Geeignet für Maus.

Kurzübersicht für SIRPA Antikörper (FITC) (ABIN2661533)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser SIRPA Antikörper ist konjugiert mit FITC

Applikation: ELISA, Immunohistochemistry (IHC), Intracellular Flow Cytometry (ICFC), Mass Cytometry (CyTOF)

Klon: P84

Produktdetails anti-SIRPA Antikörper (FITC)

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. The solution is free of unconjugated FITC.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: CD172a

Hintergrund: CD172a, also known as SIRPα, is a type I transmembrane protein with one V-set Ig-like and two C-set Ig-like domains in the extracellular portion, and two ITIM motifs and a proline-rich region in the cytoplasmic tail. CD172a is expressed by monocytes, macrophages, myeloid cells, and neuronal tissue. The phosphorylation of SIRPα ITIMs induces the recruitment and activation of the tyrosine phosphatases PTPN6 and PTPN11, resulting in the negative regulation of several biological processes. The ligands of CD172a are CD47, SP-A, and SP-D.