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LRRC32 Antikörper (APC)

LRRC32 Reaktivität: Human BCA Wirt: Maus Monoclonal 7B11 APC
Produktnummer ABIN2658317
  • Target Alle LRRC32 Antikörper anzeigen
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    Reaktivität
    • 29
    • 13
    • 9
    • 1
    Human
    Wirt
    • 20
    • 15
    • 4
    • 1
    Maus
    Klonalität
    • 21
    • 19
    Monoklonal
    Konjugat
    • 21
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Dieser LRRC32 Antikörper ist konjugiert mit APC
    Applikation
    • 21
    • 16
    • 15
    • 10
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Biochemical Assay (BCA)
    Aufreinigung
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Klon
    7B11
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product LRRC32 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Protect from prolonged exposure to light. Do not freeze.
    Lagerung
    4 °C
    Informationen zur Lagerung
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • Target
    LRRC32 (Leucine Rich Repeat Containing 32 (LRRC32))
    Andere Bezeichnung
    GARP (LRRC32 Produkte)
    Synonyme
    D11S833E antikoerper, GARP antikoerper, AI426318 antikoerper, D11S833Eh antikoerper, D7H11S833E antikoerper, EG434215 antikoerper, Garp antikoerper, leucine rich repeat containing 32 antikoerper, LRRC32 antikoerper, Lrrc32 antikoerper
    Hintergrund
    Glycoprotein A Repetitions Predominant (GARP), also known as leucine rich repeat containing 32 (LRC32), is a 80 kD type I membrane glycoprotein with 20 leucine rich repeats in the extracellular portion of the protein. GARP was found on the surface of megakaryocytes, platelets, and activated Tregs (CD4+, CD25+, FoxP3+ cells) and serves as a receptor for latent TGF-β. Recent evidence suggests that GARP may play a role in controlling suppressor function of Tregs. A mutation in GARP has been reported in a large Samaritan kindred with Usher syndrome type 1, an autosomal recessive disease characterized by profound congenital sensorineural deafness, vestibular dysfunction, and progressive visual loss. In addition, it has been found that GARP mRNA is highly amplified in different tumors, which indicates that tumor cells may use GARP to express TGF-β or to capture TGF-β from their surroundings, resulting in local suppression of anti-tumor immune responses or the induction of Tregs.
    Pathways
    Activated T Cell Proliferation
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