ICOS Antikörper (Alexa Fluor 647)

Produktnummer ABIN2657721

Dieses Hamster Monoklonal-Antikörper erkennt spezifisch ICOS in FACS und ICFC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für ICOS Antikörper (Alexa Fluor 647) (ABIN2657721)

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reaktivität: Human, Maus, Ratte

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser ICOS Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Klon: C398-4A

Produktdetails anti-ICOS Antikörper (Alexa Fluor 647)

Kreuzreaktivität: Rhesusaffen, Schwein

Aufreinigung: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Details zu ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Andere Bezeichnung: CD278

Hintergrund: ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.

Pathways: Cancer Immune Checkpoints