XBP-1s Antikörper (Alexa Fluor 647)

Produktnummer ABIN2657234

Der Alexa Fluor 647-konjugierte Maus Monoklonal anti-XBP-1s Antikörper (Klon 143F) (ABIN2657234) detektiert spezifisch XBP-1s in FACS und CyTOF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für XBP-1s Antikörper (Alexa Fluor 647) (ABIN2657234)

Target: XBP-1s

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Alexa Fluor 647

Applikation: Flow Cytometry (FACS), Mass Cytometry (CyTOF)

Klon: 143F

Produktdetails

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Antigendetails

Target: XBP-1s

Hintergrund: XBP-1 is a transcription factor containing a bZIP domain. It was first identified because of its ability to bind X-box, a conserved transcriptional element in the promoter of human HLA DR gene. XBP-1 has multiple functions. It controls MHC class II gene regulation and is also essential for differentiation of plasma cells. XBP-1 upregulates as part of the ER stress response, also known as the unfolded protein response. Unspliced XBP-1 is 261 amino acids and migrates on the SDS-PAGE around 33 kD, spliced XBP-1, recognized by clone 143F, is 371 amino acids and migrates around 55 kD.