Clusterin Antikörper (Isoform 1)

Produktnummer ABIN265125

Der Kaninchen Polyklonal anti-Clusterin Antikörper (ABIN265125) detektiert spezifisch Clusterin in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Clusterin Antikörper (Isoform 1) (ABIN265125)

Target: Clusterin (CLU)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Clusterin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Clusterin Antikörper

Bindungsspezifität: Isoform 1

Spezifität: This antibody reacts to Apolipoprotein J (Clusterin).

Aufreinigung: Purified

Immunogen: Rabbit polyclonal Clusterin antibody was raised recombinant human Clusterin isoform 1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5 - 1 μg/mL. Positive Control: Human Brain Tissue Lysate used as positive control. Clusterin is known tobe expressed in a variety of tissues and it seems to be able to bind to cells, membranesand hydrophobic proteins.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu Clusterin

Target: Clusterin (CLU)

Andere Bezeichnung: Apolipoprotein J (Apo J)

Hintergrund: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide (1). Clusterin expression is increased in Alzheimer's disease brain tissue and clusterinimmunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites (2) and it has been suggested that clusterin facilitates the conversion of diffuse bamyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression (3). Clusterin exists in at least two distinct isoforms.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2

Gen-ID: 1191

NCBI Accession: NP_976084

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling