SH2D1A Antikörper

Produktnummer ABIN265020

Dieses Anti-SH2D1A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SH2D1A in WB und IP. Geeignet für Human.

Kurzübersicht für SH2D1A Antikörper (ABIN265020)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH2D1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-SH2D1A Antikörper

Spezifität: This antibody reacts to SH2D1A.

Aufreinigung: Purified

Immunogen: Full-length recombinant SAP protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 5 - 10 μg/mL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Andere Bezeichnung: SH2D1A

Hintergrund: SLAM (Signaling Lymphocyte-Activation Molecule) is a glycosylated type-I transmembrane protein which is present on the surface of B and T cells. SLAM is a high-affinity self-ligand which, when triggered, co-activated B or T lymphocyte responses and is considered to be important in bi-directional T - B cell stimulation. SAP (SLAM-Associated Protein) has been determined to be a 15 kDa protein. SAP is believed to the genetic defect which cauases X-linked Lymphoproliferative Syndrome (XLP). SAP is thought to bind to SLAM by the SH2 domain of the SAP protein. Binding of SAP to the SLAM protein blocks the binding of SHP-2 to the phosphorylated SLAM protein which causes XLP.Synonyms: DSHP, Duncan disease SH2-protein, SAP, SH2 domain-containing protein 1A, SLAM-associated protein, Signaling lymphocytic activation molecule-associated protein, T-cell signal transduction molecule SAP

Gen-ID: 4068

NCBI Accession: NP_001108409

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process