beta Amyloid Antikörper (N-Term)

Produktnummer ABIN263686

Dieser Maus Monoklonal Antikörper detektiert spezifisch beta Amyloid in WB, IHC (p), EIA, IP und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für beta Amyloid Antikörper (N-Term) (ABIN263686)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser beta Amyloid Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 1-00E-011

Produktdetails anti-beta Amyloid Antikörper

Bindungsspezifität: AA 1-24, N-Term

Aufreinigung: Purified

Immunogen: 1-24 a. a. of beta amyloid (NAEFRHDSGYQVHHQKLVFFAEDV)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot. Immunohistochemistry on paraffin sections: 70 % , 30 minutes at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS, None

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Andere Bezeichnung: Amyloid beta

Hintergrund: Amyloid beta precursor protein gene (ABPP) encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Multiple transcript variants encoding several different isoforms have been found for this gene. Isoform APP695 is the predominant form in neuronal tissue, isoform APP751 and isoform APP770 are widely expressed in nonneuronal cells. Isoform APP751 is the most abundant form in T lymphocytes. ABPP is expressed in all fetal tissues examined with the highest levels in brain, kidney, heart and spleen with weak expression observed in liver, ABPP is induced during neuronal differentiation. In the adult brain, highest expression of ABPP gene is found in the frontal lobe of the cortex and in the anterior perisylvian cortex opercular gyri, moderate expression in the cerebellar cortex, the posterior perisylvian cortex opercular gyri and the temporal associated cortex. Weak expression is found in the striate, extra striate and motor cortices. Mutations in ABPP have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).Synonyms: Amyloid beta peptide

Pathways: Inflammasome