tau Antikörper (pSer202, pSer519)

Produktnummer ABIN2568469

Der Kaninchen Polyklonal anti-tau Antikörper (ABIN2568469) detektiert spezifisch tau in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für tau Antikörper (pSer202, pSer519) (ABIN2568469)

Target: tau (tau Protein)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser tau Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-tau Antikörper

Bindungsspezifität: pSer202, pSer519

Spezifität: The antibody detects endogenous levels of Tau only when phosphorylated at serine 519/202.

Aufreinigung: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogen: Tau (phospho Ser519/202) antibody was raised against a peptide sequence around phosphorylation site of Serine 519/202 (P-G-S (p)-P-G) derived from Human Tau.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1:500~1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store antibody at -20°C for up to one year.

Details zu tau

Target: tau (tau Protein)

Andere Bezeichnung: tau

Hintergrund: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Molekulargewicht: 85 kDa

Gen-ID: 4137

NCBI Accession: NP_058519

UniProt: P10636