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CD80 Antikörper (PE)

CD80 Reaktivität: Ratte FACS Wirt: Maus Monoclonal 3H5 PE

Produktnummer ABIN2567935

Datenblatt (PDF)

Target Alle CD80 Antikörper anzeigen

CD80
Reaktivität
151

109

46

8

6

6

1

1

1
Ratte
Wirt
92

81

21

21

19

2

1
Maus
Passende Sekundärantikörper
Klonalität
154

80

2
Monoklonal
Konjugat
97

19

19

16

12

5

4

4

4

4

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Dieser CD80 Antikörper ist konjugiert mit PE
Applikation
139

93

69

39

39

25

14

13

13

13

11

10

10

6

5

4

3

3

2

2

2

1

1

1

1

1

1

1
Flow Cytometry (FACS)

Spezifität

The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR).

Aufreinigung

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Klon

3H5

Isotyp

IgG1 kappa

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anti-CD80 (CD80) (Extracellular Domain) antibody (APC)
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CD80 Reaktivität: Human ELISA, IHC, ICC Wirt: Maus Monoclonal 2A2 unconjugated

Applikationshinweise

Optimal working dilution should be determined by the investigator.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

0.2 mg/mL

Buffer

Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Lagerung

4 °C

Informationen zur Lagerung

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Target

CD80

Andere Bezeichnung

CD80 (CD80 Produkte)

Hintergrund

The 3H5 monoclonal antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. The 3H5 antibody blocks the binding of CD80 to its ligands.

Gen-ID

25408

Pathways

T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints