Leptin Receptor Antikörper (AA 901-1000) (PE)

Produktnummer ABIN2559727

This anti-Leptin Receptor antibody (ABIN2559727) is a Rabbit Polyclonal antibody detecting Leptin Receptor in WB, FACS. Suitable for Human, Mouse, Rat, Pig.

Quick Overview for Leptin Receptor Antikörper (AA 901-1000) (PE) (ABIN2559727)

Target: Leptin Receptor (LEPR)

Reaktivität: Human, Maus, Ratte, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Leptin Receptor Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-Leptin Receptor Antikörper (PE)

Bindungsspezifität: AA 901-1000

Spezifität: This antibody will recognize the Isoform B variant only

Kreuzreaktivität: Human, Maus, Schwein, Ratte

Homologie: Dog,Cow,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Leptin receptor:901-1000/1165

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Leptin Receptor Antikörper (PE) (ABIN2559727)

Goto, Kaneko, Sato, Otsuka, Yamamoto, Goto, Yamamoto, Yamamoto, Kawachi, Madaio, Narita: "Leptin deficiency down-regulates IL-23 production in glomerular podocytes resulting in an attenuated immune response in nephrotoxic serum nephritis." in: International immunology, Vol. 28, Issue 4, pp. 197-208, (2016) (PubMed).

Details zu Leptin Receptor

Target: Leptin Receptor (LEPR)

Andere Bezeichnung: Leptin receptor (Isoform B)

Hintergrund:

Synonyms: OBR, OB-R, CD295, LEP-R, LEPRD, Leptin receptor, HuB219, OB receptor, LEPR, DB, LEPR_MOUSE

Background: Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway (By similarity).

Gen-ID: 3953

UniProt: P48357

Pathways: JAK-STAT Signalweg, AMPK Signaling, Feeding Behaviour